Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC Hydroquinine | 1 G
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Hydroquinine | 1 G
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Medchemexpress LLC Hydroquinine | 522-66-7 | 99.84% | 326.44 | 5 G
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Hydroquinine | 522-66-7 | 99.84% | 326.44 | 5 G
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Medchemexpress LLC Quinine sulfate | 549-56-4 | 97.0% | 100 MG
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Quinine sulfate from MedChemExpress is an antiarrhythmic agent. It acts as a potent, orally active, selective cytochrome P450db inhibitor and a K+ channel blocker with an IC50 of 19.9 μM. It is also used for malaria research.
- Acts as an antiarrhythmic agent.
- Functions as a potent, orally active, selective cytochrome P450db inhibitor.
- Blocks K+ channels with an IC50 of 19.9 μM.
- Suitable for malaria research.
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Medchemexpress LLC Quinine | 130-95-0 | 25 G
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Quinine is an alkaloid derived from the bark of the cinchona tree, acting as an anti-malaria agent and a potassium channel inhibitor. It inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM.
- Derived from cinchona tree bark
- Acts as an anti-malaria agent
- Functions as a potassium channel inhibitor
- Inhibits WT mouse Slo3 (KCa5.1) channel currents
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Medchemexpress LLC Quinine hydrochloride | 130-89-2 | 99.8% | 360.88 | 10 MG
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Quinine hydrochloride is an alkaloid derived from the bark of the cinchona tree, acting as an anti-malaria agent and potassium channel inhibitor. It inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV.
- Acts as an anti-malaria agent.
- Functions as a potassium channel inhibitor.
- Inhibits WT mouse Slo3 (KCa5.1) channel currents.
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Apexbio Technology LLC Mefloquine hydrochloride 51773-92-3 10mM (in 1mL DMSO)
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Mefloquine hydrochloride is a quinoline-based antimalarial compound structurally related to quinidine with demonstrated inhibitory effects on Plasmodium falciparum It functions primarily through modulation of potassium ion channels displaying an IC50 around 1 M against KvLQT1/minK channel currents and approximately 5 6 M against HERG channel currents Research indicates that mefloquine induces cellular oxidative stress modulating intracellular signaling pathways including Akt phosphorylation ERK JNK and AMPK in vitro Current studies also explore its potential cytotoxic activity toward cancer cell lines and evaluate effectiveness against urinary schistosomiasis in phase 2 clinical trials
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Medchemexpress LLC Mefloquine (Standard) | 53230-10-7 | MFCD00869324 | 378.31 | 100 MG
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Mefloquine (Standard) is the analytical standard of Mefloquine, intended for research and analytical applications. It is an orally active and potent quinoline antimalarial agent and an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. This analytical standard grade compound is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Orally active and potent quinoline antimalarial agent.
- Anti-SARS-CoV-2 entry inhibitor.
- K+ channel (KvQT1/minK) antagonist.
- Used for malaria, systemic lupus erythematosus, and cancer research.
- Analytical standard grade for qualitative, quantitative, and methodological research experiments.
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Medchemexpress LLC Cinchonine | 118-10-5 | MFCD00064372 | 99.7% | 294.39 g/mol | C19H22N2O | 50g
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Cinchonine is a natural compound present in Cinchona bark with antimalarial antitumor anti-inflammatory anti platelet-aggregation and anti-obesity properties Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3 Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1]
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Selleck Chemical LLC Mefloquine HCl S4420-100mg
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Mefloquine HCl(Mefloquin hydrochloride) is a blood schizonticide by inhibiting hemozoin formation used as an antimalarial drug
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AdipoGen Quinine HCl dihydrate
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Chemical. CAS 6119-47-7. Formula C20H24N2O2 . HCl . 2H2O. MW BD9837. Quinine hydrochloride dihydrate is isolated from the cinchona tree?s bark, is characterized by a bitter taste and shows antipyretic fever-reducing, anti-malarial, analgesic painkilling, anti-viral and anti-inflammatory properties. Quinine also possesses, at high concentrations, antibacterial properties, which suggests it has potential as an antimicrobial adjuvant. It is believed to impede the activity of enzymes associated with nucleic acid and protein biosynthesis and act as an antagonist for specific neurotransmitters, including serotonin. Quinine acts as a competitive inhibitor of monoamine oxidase MAO, an enzyme that removes neurotransmitters from the brain and a general potasssium channel blocker. Quinine is a flavor component of tonic water and bitter lemon drink mixers.
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Medchemexpress LLC Hydroquinidine | 1435-55-8 | 100.0% | 1 G
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Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker with strong anti-cancer activity across colon, pancreatic, and hepatocellular cancer cells. It is also known for its ability to prolong the QT interval and demonstrates antiarrhythmic efficacy.
- Potent ion channel blocker
- Exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
- Prolongs the QT interval
- Shows antiarrhythmic efficacy
- Demonstrates anti-clonogenic and anti-tumorigenic activities in pancreatic cancer cells
- Modulates gene expression, increasing CDKN1A, CDKN1B, and PUMA
- Reduces expression of BIRC5, AKT, MKI67, PCNA, and CCNE1 in various cancer cell lines
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Medchemexpress LLC Hydroquinidine | 1435-55-8 | 99.97% | 5 G
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Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker that exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. It also prolongs the QT interval and demonstrates antiarrhythmic efficacy.
- Potent ion channel blocker
- Strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
- Prolongs the QT interval
- Antiarrhythmic efficacy
- For research use only
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Medchemexpress LLC Hydroquinidine (Dihydroquinidine) | 1435-55-8 | 99.9% | 50 G
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Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker that demonstrates strong anti-cancer activity against colon, pancreatic, and hepatocellular cancer cells. It also prolongs the QT interval and possesses antiarrhythmic efficacy.
- Exhibits anti-clonogenic and anti-tumorigenic activities in pancreatic cancer cells in vitro.
- Gene expression profiling shows changes in CDKN1A, CDKN1B, PUMA, BIRC5, AKT, MKI67, PCNA, and CCNE1 in various cancer cell lines.
- Investigated for Brugada Syndrome in a Phase 3 clinical trial.
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Apexbio Technology LLC Cinchonine(LA40221) 118-10-5 25mg
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Cinchonine LA40221 (118-10-5) is a small-molecule inhibitor designed to modulate biological processes such as inflammation tumorigenesis malaria infection obesity and platelet aggregation Cinchonine LA40221 exerts its biological activity primarily through regulation of signaling pathways modulation of enzyme activities and induction of apoptosis via caspase-3-dependent mechanisms In in vitro studies Cinchonine LA40221 demonstrates antitumor activity with IC50 values ranging approximately from 10-100 M depending on cell types and protocols Based on these pharmacological properties Cinchonine LA40221 holds research potential in studying malaria infection models cancer cell apoptosis inflammatory responses platelet function and obesity-related metabolic pathways
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Selleck Chemical LLC Quinidine S2571-1g
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Quinidine is a pharmaceutical agent that acts as a class I antiarrhythmic agent
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